Estimating long-term treatment effects without long-term outcome data

David Rhys Bernard (Rethink Priorities), Jojo Lee and Victor Yaneng Wang (Global Priorities Institute, University of Oxford)

GPI Working Paper No. 13-2023

The surrogate index method allows policymakers to estimate long-run treatment effects before long-run outcomes are observable. We meta-analyse this approach over nine long-run RCTs in development economics, comparing surrogate estimates to estimates from actual long-run RCT outcomes. We introduce the M-lasso algorithm for constructing the surrogate approach’s first-stage predictive model and compare its performance with other surrogate estimation methods. Across methods, we find a negative bias in surrogate estimates. For the M-lasso method, in particular, we investigate reasons for this bias and quantify significant precision gains. This provides evidence that the surrogate index method incurs a bias-variance trade-off.

Other working papers

How much should governments pay to prevent catastrophes? Longtermism’s limited role – Carl Shulman (Advisor, Open Philanthropy) and Elliott Thornley (Global Priorities Institute, University of Oxford)

Longtermists have argued that humanity should significantly increase its efforts to prevent catastrophes like nuclear wars, pandemics, and AI disasters. But one prominent longtermist argument overshoots this conclusion: the argument also implies that humanity should reduce the risk of existential catastrophe even at extreme cost to the present generation. This overshoot means that democratic governments cannot use the longtermist argument to guide their catastrophe policy. …

Are we living at the hinge of history? – William MacAskill (Global Priorities Institute, Oxford University)

In the final pages of On What Matters, Volume II, Derek Parfit comments: ‘We live during the hinge of history… If we act wisely in the next few centuries, humanity will survive its most dangerous and decisive period… What now matters most is that we avoid ending human history.’ This passage echoes Parfit’s comment, in Reasons and Persons, that ‘the next few centuries will be the most important in human history’. …

Prediction: The long and the short of it – Antony Millner (University of California, Santa Barbara) and Daniel Heyen (ETH Zurich)

Commentators often lament forecasters’ inability to provide precise predictions of the long-run behaviour of complex economic and physical systems. Yet their concerns often conflate the presence of substantial long-run uncertainty with the need for long-run predictability; short-run predictions can partially substitute for long-run predictions if decision-makers can adjust their activities over time. …